H2N2V1, Main, Exploration, bibRecord, 001701

Gastric mucosal lesions in influenza virus infected mice: role of gastric lipid peroxidation.

Identifieur interne : 001701 ( Main/Exploration ); précédent : 001700; suivant : 001702

Gastric mucosal lesions in influenza virus infected mice: role of gastric lipid peroxidation.

Auteurs : M. Mileva [Bulgarie] ; K. Marazova [Bulgarie] ; A. S. Galabov [Bulgarie]

Source :

Methods and findings in experimental and clinical pharmacology [ 0379-0355 ] ; 2003-09.

RBID : Hal:pasteur-00736410

Abstract

The present study provides direct experimental proof that the combination of influenza virus infection A/Aichi/2/68 (H3N3) with different models of oxidative stress, such as immobilization, cold and cold-restraint, is associated with graduated oxidative disturbances in the stomach of mice, despite the absence of virus replication and inflammation in this tissue. It was found that experimental influenza virus infection is accompanied with significant changes in gastric mucosal integrity, as well as an increase in the products of lipid peroxidation in the stomachs of mice. Preliminary exposure of mice to immobilization stress and subsequent inoculation of influenza virus did not significantly influence gastric ulceration or lipid peroxidation compared with infected mice. Cold stress resulted in a significant decrease in the index of stomach ulceration and did not influence the fluorescent products of lipid peroxidation and MDA compared with infected animals. The simultaneous application of cold-restraint stress and influenza virus infection provoked synergism in the activity of all factors on the parameters under investigation. Ulceration increased approximately two-fold, as did the amount of fluorescent products of lipid peroxidation and MDA, compared with influenza virus-infected and non-stressed animals.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00736410

DOI: 10.1358/mf.2003.25.7.778090

Affiliations:

Bulgarie

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000111
to stream Hal, to step Curation: 000111
to stream Hal, to step Checkpoint: 000330
to stream Main, to step Merge: 001733
to stream Main, to step Curation: 001701

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>The present study provides direct experimental proof that the combination of influenza virus infection A/Aichi/2/68 (H3N3) with different models of oxidative stress, such as immobilization, cold and cold-restraint, is associated with graduated oxidative disturbances in the stomach of mice, despite the absence of virus replication and inflammation in this tissue. It was found that experimental influenza virus infection is accompanied with significant changes in gastric mucosal integrity, as well as an increase in the products of lipid peroxidation in the stomachs of mice. Preliminary exposure of mice to immobilization stress and subsequent inoculation of influenza virus did not significantly influence gastric ulceration or lipid peroxidation compared with infected mice. Cold stress resulted in a significant decrease in the index of stomach ulceration and did not influence the fluorescent products of lipid peroxidation and MDA compared with infected animals. The simultaneous application of cold-restraint stress and influenza virus infection provoked synergism in the activity of all factors on the parameters under investigation. Ulceration increased approximately two-fold, as did the amount of fluorescent products of lipid peroxidation and MDA, compared with influenza virus-infected and non-stressed animals.</p>
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Gastric mucosal lesions in influenza virus infected mice: role of gastric lipid peroxidation.

Gastric mucosal lesions in influenza virus infected mice: role of gastric lipid peroxidation.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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